New Biomarkers Catch Tau Before It Tangles | ALZFORUM
Feb 18, 2025 · Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s disease. …
Tau (AT8); Phospho Tau (Ser 202, Thr 205) - ALZFORUM
Feb 6, 2024 · Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease. Recognizes …
Triple Trouble: New Knock-in Turbocharges Tauopathy
May 1, 2025 · They accumulated hyperphosphorylated tau in their brains and lost synapses by approximately 15 months of age, but they had no tau oligomers capable of seeding …
Tau (PHF-1) | ALZFORUM
Feb 5, 2024 · PHF-1 reacts with tau phosphorylated at serine-396 and serine-404. Western blot of recombinant human tau phosphorylated in vitro with GSK3β, probed with PHF-1. WT, wild …
ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
Feb 1, 2025 · To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time. It showed that ApoE3Ch clings onto tau …
Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
Dec 29, 2022 · In the December 27 Brain, Karikari reported that plasma concentration of these brain-derived forms of tau (BD-tau) tracked with cerebrospinal fluid markers of amyloid …
Tau (CP-13) - ALZFORUM
Feb 7, 2024 · This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202. Recognizes tau …
Widely Used Tau Seeding Assay Challenged - ALZFORUM
May 22, 2020 · Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey. In a preprint on bioRxiv, …
JNJ-64042056 | ALZFORUM
In both wild-type C57BL/6 and P301L mutant tau transgenic mice, a three-month regimen of subcutaneous ACI-35 injection rapidly generated high titers of polyclonal IgG antibodies …
Large Tau-PET Studies Confirm: Tangles Foretell Decline
Jul 16, 2025 · Two studies analyzed tau-PET scans from thousands of participants in dozens of cohorts. Tangle prevalence increased with age among cognitively normal people, but …